Lenient rate control versus strict rate control for atrial fibrillation: a protocol for the Danish Atrial Fibrillation (DanAF) randomised clinical trial

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Lenient versus strict rate control in atrial fibrillation.

At the turn of the century, a spate of randomized, controlled trials (RCTs) compared the 2 main pharmacological options for rhythm management for atrial fibrillation (AF): repeated attempts to restore and maintain sinus rhythm (rhythm control) and controlling the heart rate without any specific attempts to restore and maintain sinus rhythm (rate control) (1). Largely driven by results of the 2 ...

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Lenient versus strict rate control in patients with atrial fibrillation.

BACKGROUND Rate control is often the therapy of choice for atrial fibrillation. Guidelines recommend strict rate control, but this is not based on clinical evidence. We hypothesized that lenient rate control is not inferior to strict rate control for preventing cardiovascular morbidity and mortality in patients with permanent atrial fibrillation. METHODS We randomly assigned 614 patients with...

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intravenous amiodarone versus digoxin in atrial fibrillation rate control; a clinical trial

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Rate versus rhythm control in atrial fibrillation.

OBJECTIVE To determine whether rate control is a viable initial treatment approach in persistent atrial fibrillation (AF) through the evaluation of recently completed trials comparing rate and rhythm control. DATA SOURCES Biomedical literature was obtained through MEDLINE (1966-December 2003) and the Iowa database. STUDY SELECTION AND DATA EXTRACTION Articles identified from the biomedical ...

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Rate control in atrial fibrillation.

Untreated atrial fibrillation is usually associated with a rapid, irregular ventricular response and is often accompanied by symptoms including palpitations, fatigue, dyspnea, and dizziness. It is widely accepted that slowing the ventricular response, both at rest and during activity, with the use of drugs that prolong the refractory period of the atrioventricular (AV) node (so-called rate-cont...

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ژورنال

عنوان ژورنال: BMJ Open

سال: 2021

ISSN: 2044-6055,2044-6055

DOI: 10.1136/bmjopen-2020-044744